Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis

Left ventricular hypertrophy (LVH) is a major risk factor for cardiovascular morbidity and mortality. Pathological LVH engages transcriptional programs including reactivation of canonical fetal genes and those inducing fibrosis. Histone lysine demethylases (KDMs) are emerging regulators of transcrip...

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Pubblicato in:Nat Commun
Autori principali: Zhang, Qing-Jun, Tran, Tram Anh T., Wang, Ming, Ranek, Mark J., Kokkonen-Simon, Kristen M., Gao, Jason, Luo, Xiang, Tan, Wei, Kyrychenko, Viktoriia, Liao, Lan, Xu, Jianming, Hill, Joseph A., Olson, Eric N., Kass, David A., Martinez, Elisabeth D., Liu, Zhi-Ping
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286331/
https://ncbi.nlm.nih.gov/pubmed/30531796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07173-2
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