Transmembrane but not soluble helices fold inside the ribosome tunnel

Integral membrane proteins are assembled into the ER membrane via a continuous ribosome-translocon channel. The hydrophobicity and thickness of the core of the membrane bilayer leads to the expectation that transmembrane (TM) segments minimize the cost of harbouring polar polypeptide backbones by ad...

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Publicat a:Nat Commun
Autors principals: Bañó-Polo, Manuel, Baeza-Delgado, Carlos, Tamborero, Silvia, Hazel, Anthony, Grau, Brayan, Nilsson, IngMarie, Whitley, Paul, Gumbart, James C., von Heijne, Gunnar, Mingarro, Ismael
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286305/
https://ncbi.nlm.nih.gov/pubmed/30531789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07554-7
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