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A programmable dual RNA-guided DNA endonuclease in adaptive bacterial immunity
CRISPR/Cas systems provide bacteria and archaea with adaptive immunity against viruses and plasmids by using crRNAs to guide the silencing of invading nucleic acids. We show here that in a subset of these systems, the mature crRNA base-paired to trans-activating tracrRNA forms a two-RNA structure th...
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| Pubblicato in: | Science |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6286148/ https://ncbi.nlm.nih.gov/pubmed/22745249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1225829 |
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