Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure

BACKGROUND: Hepatic encephalopathy (HE), a severe neuropsychiatric complication, is associated with increased blood levels of ammonia and bile acids (BAs). We sought to determine (1) whether abnormally increased blood BAs in liver cirrhotic patients with HE is caused by elevation of apical sodium-de...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:EBioMedicine
Main Authors: Xie, Guoxiang, Wang, Xiaoning, Jiang, Runqiu, Zhao, Aihua, Yan, Jingyu, Zheng, Xiaojiao, Huang, Fengjie, Liu, Xinzhu, Panee, Jun, Rajani, Cynthia, Yao, Chun, Yu, Herbert, Jia, Weiping, Sun, Beicheng, Liu, Ping, Jia, Wei
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2018
Teme:
Research paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284422/
https://ncbi.nlm.nih.gov/pubmed/30344125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.10.030
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