Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure

BACKGROUND: Hepatic encephalopathy (HE), a severe neuropsychiatric complication, is associated with increased blood levels of ammonia and bile acids (BAs). We sought to determine (1) whether abnormally increased blood BAs in liver cirrhotic patients with HE is caused by elevation of apical sodium-de...

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Vydáno v:EBioMedicine
Hlavní autoři: Xie, Guoxiang, Wang, Xiaoning, Jiang, Runqiu, Zhao, Aihua, Yan, Jingyu, Zheng, Xiaojiao, Huang, Fengjie, Liu, Xinzhu, Panee, Jun, Rajani, Cynthia, Yao, Chun, Yu, Herbert, Jia, Weiping, Sun, Beicheng, Liu, Ping, Jia, Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2018
Témata:
Research paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284422/
https://ncbi.nlm.nih.gov/pubmed/30344125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.10.030
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