Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure

BACKGROUND: Hepatic encephalopathy (HE), a severe neuropsychiatric complication, is associated with increased blood levels of ammonia and bile acids (BAs). We sought to determine (1) whether abnormally increased blood BAs in liver cirrhotic patients with HE is caused by elevation of apical sodium-de...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EBioMedicine
Prif Awduron: Xie, Guoxiang, Wang, Xiaoning, Jiang, Runqiu, Zhao, Aihua, Yan, Jingyu, Zheng, Xiaojiao, Huang, Fengjie, Liu, Xinzhu, Panee, Jun, Rajani, Cynthia, Yao, Chun, Yu, Herbert, Jia, Weiping, Sun, Beicheng, Liu, Ping, Jia, Wei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2018
Pynciau:
Research paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284422/
https://ncbi.nlm.nih.gov/pubmed/30344125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.10.030
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