Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure

BACKGROUND: Hepatic encephalopathy (HE), a severe neuropsychiatric complication, is associated with increased blood levels of ammonia and bile acids (BAs). We sought to determine (1) whether abnormally increased blood BAs in liver cirrhotic patients with HE is caused by elevation of apical sodium-de...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Xie, Guoxiang, Wang, Xiaoning, Jiang, Runqiu, Zhao, Aihua, Yan, Jingyu, Zheng, Xiaojiao, Huang, Fengjie, Liu, Xinzhu, Panee, Jun, Rajani, Cynthia, Yao, Chun, Yu, Herbert, Jia, Weiping, Sun, Beicheng, Liu, Ping, Jia, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284422/
https://ncbi.nlm.nih.gov/pubmed/30344125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.10.030
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