PDX models recapitulate the genetic and epigenetic landscape of pediatric T‐cell leukemia

We compared 24 primary pediatric T‐cell acute lymphoblastic leukemias (T‐ALL) collected at the time of initial diagnosis and relapse from 12 patients and 24 matched patient‐derived xenografts (PDXs). DNA methylation profile was preserved in PDX mice in 97.5% of the promoters (ρ = 0.99). Similarly, t...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:EMBO Mol Med
Autors principals: Richter‐Pechańska, Paulina, Kunz, Joachim B, Bornhauser, Beat, von Knebel Doeberitz, Caroline, Rausch, Tobias, Erarslan‐Uysal, Büşra, Assenov, Yassen, Frismantas, Viktoras, Marovca, Blerim, Waszak, Sebastian M, Zimmermann, Martin, Seemann, Julia, Happich, Margit, Stanulla, Martin, Schrappe, Martin, Cario, Gunnar, Escherich, Gabriele, Bakharevich, Kseniya, Kirschner‐Schwabe, Renate, Eckert, Cornelia, Muckenthaler, Martina U, Korbel, Jan O, Bourquin, Jean‐Pierre, Kulozik, Andreas E
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284381/
https://ncbi.nlm.nih.gov/pubmed/30389682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201809443
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars