PDX models recapitulate the genetic and epigenetic landscape of pediatric T‐cell leukemia

We compared 24 primary pediatric T‐cell acute lymphoblastic leukemias (T‐ALL) collected at the time of initial diagnosis and relapse from 12 patients and 24 matched patient‐derived xenografts (PDXs). DNA methylation profile was preserved in PDX mice in 97.5% of the promoters (ρ = 0.99). Similarly, t...

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Библиографические подробности
Опубликовано в: :EMBO Mol Med
Главные авторы: Richter‐Pechańska, Paulina, Kunz, Joachim B, Bornhauser, Beat, von Knebel Doeberitz, Caroline, Rausch, Tobias, Erarslan‐Uysal, Büşra, Assenov, Yassen, Frismantas, Viktoras, Marovca, Blerim, Waszak, Sebastian M, Zimmermann, Martin, Seemann, Julia, Happich, Margit, Stanulla, Martin, Schrappe, Martin, Cario, Gunnar, Escherich, Gabriele, Bakharevich, Kseniya, Kirschner‐Schwabe, Renate, Eckert, Cornelia, Muckenthaler, Martina U, Korbel, Jan O, Bourquin, Jean‐Pierre, Kulozik, Andreas E
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2018
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284381/
https://ncbi.nlm.nih.gov/pubmed/30389682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201809443
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