PDX models recapitulate the genetic and epigenetic landscape of pediatric T‐cell leukemia

We compared 24 primary pediatric T‐cell acute lymphoblastic leukemias (T‐ALL) collected at the time of initial diagnosis and relapse from 12 patients and 24 matched patient‐derived xenografts (PDXs). DNA methylation profile was preserved in PDX mice in 97.5% of the promoters (ρ = 0.99). Similarly, t...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Richter‐Pechańska, Paulina, Kunz, Joachim B, Bornhauser, Beat, von Knebel Doeberitz, Caroline, Rausch, Tobias, Erarslan‐Uysal, Büşra, Assenov, Yassen, Frismantas, Viktoras, Marovca, Blerim, Waszak, Sebastian M, Zimmermann, Martin, Seemann, Julia, Happich, Margit, Stanulla, Martin, Schrappe, Martin, Cario, Gunnar, Escherich, Gabriele, Bakharevich, Kseniya, Kirschner‐Schwabe, Renate, Eckert, Cornelia, Muckenthaler, Martina U, Korbel, Jan O, Bourquin, Jean‐Pierre, Kulozik, Andreas E
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284381/
https://ncbi.nlm.nih.gov/pubmed/30389682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201809443
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