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Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesis

BACKGROUND: DNA is subject to constant chemical modification and damage, which eventually results in variable mutation rates throughout the genome. Although detailed molecular mechanisms of DNA damage and repair are well understood, damage impact and execution of repair across a genome remain poorly...

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Bibliografische gegevens
Gepubliceerd in:Genome Biol
Hoofdauteurs: Poetsch, Anna R., Boulton, Simon J., Luscombe, Nicholas M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284305/
https://ncbi.nlm.nih.gov/pubmed/30526646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1582-2
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