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Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesis

BACKGROUND: DNA is subject to constant chemical modification and damage, which eventually results in variable mutation rates throughout the genome. Although detailed molecular mechanisms of DNA damage and repair are well understood, damage impact and execution of repair across a genome remain poorly...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Poetsch, Anna R., Boulton, Simon J., Luscombe, Nicholas M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284305/
https://ncbi.nlm.nih.gov/pubmed/30526646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1582-2
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