Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway

The mechanisms by which exposure to heparin initiates antibody responses in many, if not most, recipients are poorly understood. We recently demonstrated that antigenic platelet factor 4 (PF4)/heparin complexes activate complement in plasma and bind to B cells. Here, we describe how this process is...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Khandelwal, Sanjay, Ravi, Joann, Rauova, Lubica, Johnson, Alexandra, Lee, Grace M., Gilner, Jennifer B., Gunti, Sreenivasulu, Notkins, Abner L., Kuchibhatla, Maragatha, Frank, Michael, Poncz, Mortimer, Cines, Douglas B., Arepally, Gowthami M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2018
Fag:
Plenary Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284214/
https://ncbi.nlm.nih.gov/pubmed/30309891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-03-834598
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