Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway

The mechanisms by which exposure to heparin initiates antibody responses in many, if not most, recipients are poorly understood. We recently demonstrated that antigenic platelet factor 4 (PF4)/heparin complexes activate complement in plasma and bind to B cells. Here, we describe how this process is...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Khandelwal, Sanjay, Ravi, Joann, Rauova, Lubica, Johnson, Alexandra, Lee, Grace M., Gilner, Jennifer B., Gunti, Sreenivasulu, Notkins, Abner L., Kuchibhatla, Maragatha, Frank, Michael, Poncz, Mortimer, Cines, Douglas B., Arepally, Gowthami M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2018
Soggetti:
Plenary Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284214/
https://ncbi.nlm.nih.gov/pubmed/30309891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-03-834598
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