Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway

The mechanisms by which exposure to heparin initiates antibody responses in many, if not most, recipients are poorly understood. We recently demonstrated that antigenic platelet factor 4 (PF4)/heparin complexes activate complement in plasma and bind to B cells. Here, we describe how this process is...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Blood
Egile Nagusiak: Khandelwal, Sanjay, Ravi, Joann, Rauova, Lubica, Johnson, Alexandra, Lee, Grace M., Gilner, Jennifer B., Gunti, Sreenivasulu, Notkins, Abner L., Kuchibhatla, Maragatha, Frank, Michael, Poncz, Mortimer, Cines, Douglas B., Arepally, Gowthami M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2018
Gaiak:
Plenary Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284214/
https://ncbi.nlm.nih.gov/pubmed/30309891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-03-834598
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak