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Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway
The mechanisms by which exposure to heparin initiates antibody responses in many, if not most, recipients are poorly understood. We recently demonstrated that antigenic platelet factor 4 (PF4)/heparin complexes activate complement in plasma and bind to B cells. Here, we describe how this process is...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Blood |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society of Hematology
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6284214/ https://ncbi.nlm.nih.gov/pubmed/30309891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-03-834598 |
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