Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway

The mechanisms by which exposure to heparin initiates antibody responses in many, if not most, recipients are poorly understood. We recently demonstrated that antigenic platelet factor 4 (PF4)/heparin complexes activate complement in plasma and bind to B cells. Here, we describe how this process is...

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發表在:Blood
Main Authors: Khandelwal, Sanjay, Ravi, Joann, Rauova, Lubica, Johnson, Alexandra, Lee, Grace M., Gilner, Jennifer B., Gunti, Sreenivasulu, Notkins, Abner L., Kuchibhatla, Maragatha, Frank, Michael, Poncz, Mortimer, Cines, Douglas B., Arepally, Gowthami M.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2018
主題:
Plenary Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284214/
https://ncbi.nlm.nih.gov/pubmed/30309891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-03-834598
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