A SIRT1-centered circuitry regulates breast cancer stemness and metastasis

Cancer stem cell (CSC)-dictated intratumor heterogeneity accounts for the majority of drug-resistance and distant metastases of breast cancers. Here, we identify a SIRT1-PRRX1-KLF4-ALDH1 circuitry, which couples CSCs, chemo-resistance, metastasis and aging. Pro-longevity protein SIRT1 deacetylates a...

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Bibliografski detalji
Izdano u:Oncogene
Glavni autori: Shi, Lei, Tang, Xiaolong, Qian, Minxian, Liu, Zuojun, Meng, Fanbiao, Fu, Li, Wang, Zimei, Zhu, Wei-Guo, Huang, Jian-Dong, Zhou, Zhongjun, Liu, Baohua
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283862/
https://ncbi.nlm.nih.gov/pubmed/30038266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0370-5
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