Vascular endothelium–targeted Sirt7 gene therapy rejuvenates blood vessels and extends life span in a Hutchinson-Gilford progeria model

Vascular dysfunction is a typical characteristic of aging, but its contributing roles to systemic aging and the therapeutic potential are lacking experimental evidence. Here, we generated a knock-in mouse model with the causative Hutchinson-Gilford progeria syndrome (HGPS) Lmna(G609G) mutation, call...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Sun, Shimin, Qin, Weifeng, Tang, Xiaolong, Meng, Yuan, Hu, Wenjing, Zhang, Shuju, Qian, Minxian, Liu, Zuojun, Cao, Xinyue, Pang, Qiuxiang, Zhao, Bosheng, Wang, Zimei, Zhou, Zhongjun, Liu, Baohua
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7030934/
https://ncbi.nlm.nih.gov/pubmed/32128409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay5556
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