HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migration

NAD(+)-dependent SIRT7 deacylase plays essential roles in ribosome biogenesis, stress response, genome integrity, metabolism and aging, while how it is transcriptionally regulated is still largely unclear. TGF-β signaling is highly conserved in multicellular organisms, regulating cell growth, cancer...

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Podrobná bibliografie
Vydáno v:Nucleic Acids Res
Hlavní autoři: Tang, Xiaolong, Li, Guo, Su, Fengting, Cai, Yanlin, Shi, Lei, Meng, Yuan, Liu, Zuojun, Sun, Jie, Wang, Ming, Qian, Minxian, Wang, Zimei, Xu, Xingzhi, Cheng, Yong-Xian, Zhu, Wei-Guo, Liu, Baohua
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102950/
https://ncbi.nlm.nih.gov/pubmed/31970414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa039
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