An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma

Obesity increases the risk of hepatocellular carcinoma (HCC) especially in men, but the molecular mechanism remains obscure. Here, we show that an androgen receptor (AR)-driven oncogene, cell cycle-related kinase (CCRK), collaborates with obesity-induced pro-inflammatory signaling to promote non-alc...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Sun, Hanyong, Yang, Weiqin, Tian, Yuan, Zeng, Xuezhen, Zhou, Jingying, Mok, Myth T. S., Tang, Wenshu, Feng, Yu, Xu, Liangliang, Chan, Anthony W. H., Tong, Joanna H., Cheung, Yue-Sun, Lai, Paul B. S., Wang, Hector K. S., Tsang, Shun-Wa, Chow, King-Lau, Hu, Mengying, Liu, Rihe, Huang, Leaf, Yang, Bing, Yang, Pengyuan, To, Ka-Fai, Sung, Joseph J. Y., Wong, Grace L. H., Wong, Vincent W. S., Cheng, Alfred S. L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283830/
https://ncbi.nlm.nih.gov/pubmed/30523261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07402-8
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