Anilinoquinoline based inhibitors of trypanosomatid proliferation

We recently reported the medicinal chemistry re-optimization of a series of compounds derived from the human tyrosine kinase inhibitor, lapatinib, for activity against Plasmodium falciparum. From this same library of compounds, we now report potent compounds against Trypanosoma brucei brucei (which...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Negl Trop Dis
Auteurs principaux: Ferrins, Lori, Sharma, Amrita, Thomas, Sarah M., Mehta, Naimee, Erath, Jessey, Tanghe, Scott, Leed, Susan E., Rodriguez, Ana, Mensa-Wilmot, Kojo, Sciotti, Richard J., Gillingwater, Kirsten, Pollastri, Michael P.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283615/
https://ncbi.nlm.nih.gov/pubmed/30475800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0006834
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