Incompatibilities in Mismatch Repair Genes MLH1-PMS1 Contribute to a Wide Range of Mutation Rates in Human Isolates of Baker’s Yeast

Laboratory baker’s yeast strains bearing an incompatible combination of MLH1 and PMS1 mismatch repair alleles are mutators that can adapt more rapidly to stress, but do so at the cost of long-term fitness. We identified 18 baker’s yeast isolates from 1011 surveyed that contain the incompatible MLH1-...

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Bibliographic Details
Published in:Genetics
Main Authors: Raghavan, Vandana, Bui, Duyen T., Al-Sweel, Najla, Friedrich, Anne, Schacherer, Joseph, Aquadro, Charles F., Alani, Eric
Format: Artigo
Language:Inglês
Published: Genetics Society of America 2018
Subjects:
Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283166/
https://ncbi.nlm.nih.gov/pubmed/30348651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.118.301550
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