Incompatibilities in Mismatch Repair Genes MLH1-PMS1 Contribute to a Wide Range of Mutation Rates in Human Isolates of Baker’s Yeast

Laboratory baker’s yeast strains bearing an incompatible combination of MLH1 and PMS1 mismatch repair alleles are mutators that can adapt more rapidly to stress, but do so at the cost of long-term fitness. We identified 18 baker’s yeast isolates from 1011 surveyed that contain the incompatible MLH1-...

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Detalles Bibliográficos
Publicado en:Genetics
Main Authors: Raghavan, Vandana, Bui, Duyen T., Al-Sweel, Najla, Friedrich, Anne, Schacherer, Joseph, Aquadro, Charles F., Alani, Eric
Formato: Artigo
Idioma:Inglês
Publicado: Genetics Society of America 2018
Assuntos:
Investigations
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283166/
https://ncbi.nlm.nih.gov/pubmed/30348651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.118.301550
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