Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP3 inflammasome activation in APP/PS1 transgenic mice

BACKGROUND: Activated microglia‐mediated inflammation plays a key role in the pathogenesis of Alzheimer’s disease (AD). In addition, chronic activation of NLRP3 inflammasomes triggered by amyloid β peptide (Aβ) in microglia contributes to persistent neuroinflammation. Here, the primary goal was to a...

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Dades bibliogràfiques
Publicat a:CNS Neurosci Ther
Autors principals: Feng, Jie, Wang, Jing‐Xue, Du, Ye‐Hong, Liu, Ying, Zhang, Wei, Chen, Jing‐Fei, Liu, Yuan‐Jie, Zheng, Min, Wang, Ke‐Jian, He, Gui‐Qiong
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282966/
https://ncbi.nlm.nih.gov/pubmed/29869390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12983
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