The Broad Aryl Acid Specificity of the Amide Bond Synthetase McbA Suggests Potential for the Biocatalytic Synthesis of Amides

Amide bond formation is one of the most important reactions in pharmaceutical synthetic chemistry. The development of sustainable methods for amide bond formation, including those that are catalyzed by enzymes, is therefore of significant interest. The ATP‐dependent amide bond synthetase (ABS) enzym...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Petchey, Mark, Cuetos, Anibal, Rowlinson, Benjamin, Dannevald, Stephanie, Frese, Amina, Sutton, Peter W., Lovelock, Sarah, Lloyd, Richard C., Fairlamb, Ian J. S., Grogan, Gideon
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282839/
https://ncbi.nlm.nih.gov/pubmed/30035356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201804592
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