Modulation of glucocorticoid receptor in human epileptic endothelial cells impacts drug biotransformation in an in vitro blood–brain barrier model

OBJECTIVE: Nuclear receptors and cytochrome P450 (CYP) regulate hepatic metabolism of several drugs. Nuclear receptors are expressed at the neurovascular unit of patients with drug‐resistant epilepsy. We studied whether glucocorticoid receptor (GR) silencing or inhibition in human epileptic brain en...

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Bibliografske podrobnosti
izdano v:Epilepsia
Main Authors: Ghosh, Chaitali, Hossain, Mohammed, Mishra, Saurabh, Khan, Sameena, Gonzalez‐Martinez, Jorge, Marchi, Nicola, Janigro, Damir, Bingaman, William, Najm, Imad
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Full‐length Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282717/
https://ncbi.nlm.nih.gov/pubmed/30264400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.14567
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