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Pattern of P450 expression at the human blood–brain barrier: Roles of epileptic condition and laminar flow

PURPOSE: P450 enzymes (CYPs) play a major role in hepatic drug metabolism. It is unclear whether these enzymes are functionally expressed by the diseased human blood–brain barrier (BBB) and are involved in local drug metabolism or response. We have evaluated the cerebrovascular CYP expression and fu...

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Bibliografiske detaljer
Main Authors: Ghosh, Chaitali, Gonzalez-Martinez, Jorge, Hossain, Mohammed, Cucullo, Luca, Fazio, Vincent, Janigro, Damir, Marchi, Nicola
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386640/
https://ncbi.nlm.nih.gov/pubmed/20074231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1528-1167.2009.02428.x
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