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Pattern of P450 expression at the human blood–brain barrier: Roles of epileptic condition and laminar flow
PURPOSE: P450 enzymes (CYPs) play a major role in hepatic drug metabolism. It is unclear whether these enzymes are functionally expressed by the diseased human blood–brain barrier (BBB) and are involved in local drug metabolism or response. We have evaluated the cerebrovascular CYP expression and fu...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3386640/ https://ncbi.nlm.nih.gov/pubmed/20074231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1528-1167.2009.02428.x |
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