Design and Synthesis of Bioisosteres of Acylhydrazones as Stable Inhibitors of the Aspartic Protease Endothiapepsin

Acylhydrazone‐based dynamic combinatorial chemistry (DCC) is a powerful strategy for the rapid identification of novel hits. Even though acylhydrazones are important structural motifs in medicinal chemistry, their further progression in development may be hampered by major instability and potential...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Jumde, Varsha R., Mondal, Milon, Gierse, Robin M., Unver, M. Yagiz, Magari, Francesca, van Lier, Roos C. W., Heine, Andreas, Klebe, Gerhard, Hirsch, Anna K. H.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282583/
https://ncbi.nlm.nih.gov/pubmed/30178575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800446
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