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Design and Synthesis of Bioisosteres of Acylhydrazones as Stable Inhibitors of the Aspartic Protease Endothiapepsin

Acylhydrazone‐based dynamic combinatorial chemistry (DCC) is a powerful strategy for the rapid identification of novel hits. Even though acylhydrazones are important structural motifs in medicinal chemistry, their further progression in development may be hampered by major instability and potential...

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Bibliografske podrobnosti
izdano v:ChemMedChem
Main Authors: Jumde, Varsha R., Mondal, Milon, Gierse, Robin M., Unver, M. Yagiz, Magari, Francesca, van Lier, Roos C. W., Heine, Andreas, Klebe, Gerhard, Hirsch, Anna K. H.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282583/
https://ncbi.nlm.nih.gov/pubmed/30178575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800446
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