Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach

Pharmacophore searches that include anchors, fragments contributing above average to receptor binding, combined with one‐step syntheses are a powerful approach for the fast discovery of novel bioactive molecules. Here, we are presenting a pipeline for the rapid and efficient discovery of aspartyl pr...

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Foilsithe in:ChemMedChem
Main Authors: Konstantinidou, Markella, Magari, Francesca, Sutanto, Fandi, Haupenthal, Jörg, Jumde, Varsha R., Ünver, M. Yagiz, Heine, Andreas, Camacho, Carlos Jamie, Hirsch, Anna K. H., Klebe, Gerhard, Dömling, Alexander
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2020
Ábhair:
Communications
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7317454/
https://ncbi.nlm.nih.gov/pubmed/32187447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000024
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