A carregar...
Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK (a) Shifts Mislead Popular Bioisosterism Concepts
Medicinal‐chemistry optimization follows strategies replacing functional groups and attaching larger substituents at a promising lead scaffold. Well‐established bioisosterism rules are considered, however, it is difficult to estimate whether the introduced modifications really match the required pro...
Na minha lista:
| Publicado no: | Angew Chem Int Ed Engl |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7821265/ https://ncbi.nlm.nih.gov/pubmed/33021032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202011295 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|