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Structure-Based Optimization of Inhibitors of the Aspartic Protease Endothiapepsin
Aspartic proteases are a class of enzymes that play a causative role in numerous diseases such as malaria (plasmepsins), Alzheimer’s disease (β-secretase), fungal infections (secreted aspartic proteases), and hypertension (renin). We have chosen endothiapepsin as a model enzyme of this class of enzy...
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| Publicado no: | Int J Mol Sci |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4581293/ https://ncbi.nlm.nih.gov/pubmed/26287174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms160819184 |
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