Discovery and Structure-Based Optimization of Adenain Inhibitors

[Image: see text] The cysteine protease adenain is the essential protease of adenovirus and, as such, represents a promising target for the treatment of ocular and other adenoviral infections. Through a concise two-pronged hit discovery approach we identified tetrapeptide nitrile 1 and pyrimidine ni...

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Detalhes bibliográficos
Main Authors: Mac Sweeney, Aengus, Grosche, Philipp, Ellis, David, Combrink, Keith, Erbel, Paul, Hughes, Nicola, Sirockin, Finton, Melkko, Samu, Bernardi, Anna, Ramage, Paul, Jarousse, Nadine, Altmann, Eva
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137446/
https://ncbi.nlm.nih.gov/pubmed/25147618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500224t
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