NmeCas9 is an intrinsically high-fidelity genome-editing platform

BACKGROUND: The development of CRISPR genome editing has transformed biomedical research. Most applications reported thus far rely upon the Cas9 protein from Streptococcus pyogenes SF370 (SpyCas9). With many RNA guides, wildtype SpyCas9 can induce significant levels of unintended mutations at near-c...

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Bibliografiska uppgifter
I publikationen:Genome Biol
Huvudupphovsmän: Amrani, Nadia, Gao, Xin D., Liu, Pengpeng, Edraki, Alireza, Mir, Aamir, Ibraheim, Raed, Gupta, Ankit, Sasaki, Kanae E., Wu, Tong, Donohoue, Paul D., Settle, Alexander H., Lied, Alexandra M., McGovern, Kyle, Fuller, Chris K., Cameron, Peter, Fazzio, Thomas G., Zhu, Lihua Julie, Wolfe, Scot A., Sontheimer, Erik J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2018
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282386/
https://ncbi.nlm.nih.gov/pubmed/30518407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1591-1
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