NmeCas9 is an intrinsically high-fidelity genome-editing platform

BACKGROUND: The development of CRISPR genome editing has transformed biomedical research. Most applications reported thus far rely upon the Cas9 protein from Streptococcus pyogenes SF370 (SpyCas9). With many RNA guides, wildtype SpyCas9 can induce significant levels of unintended mutations at near-c...

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Библиографические подробности
Опубликовано в: :Genome Biol
Главные авторы: Amrani, Nadia, Gao, Xin D., Liu, Pengpeng, Edraki, Alireza, Mir, Aamir, Ibraheim, Raed, Gupta, Ankit, Sasaki, Kanae E., Wu, Tong, Donohoue, Paul D., Settle, Alexander H., Lied, Alexandra M., McGovern, Kyle, Fuller, Chris K., Cameron, Peter, Fazzio, Thomas G., Zhu, Lihua Julie, Wolfe, Scot A., Sontheimer, Erik J.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2018
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282386/
https://ncbi.nlm.nih.gov/pubmed/30518407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1591-1
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