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Orthogonal Cas9–Cas9 chimeras provide a versatile platform for genome editing
The development of robust, versatile and accurate toolsets is critical to facilitate therapeutic genome editing applications. Here we establish RNA-programmable Cas9-Cas9 chimeras, in single- and dual-nuclease formats, as versatile genome engineering systems. In both of these formats, Cas9-Cas9 fusi...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6242970/ https://ncbi.nlm.nih.gov/pubmed/30451839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07310-x |
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