Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins

In their natural settings, CRISPR-Cas systems play crucial roles in bacterial and archaeal adaptive immunity to protect against phages and other mobile genetic elements, and they are also widely used as genome engineering technologies. Previously we discovered bacteriophage-encoded Cas9-specific ant...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Lee, Jooyoung, Mir, Aamir, Edraki, Alireza, Garcia, Bianca, Amrani, Nadia, Lou, Hannah E., Gainetdinov, Ildar, Pawluk, April, Ibraheim, Raed, Gao, Xin D., Liu, Pengpeng, Davidson, Alan R., Maxwell, Karen L., Sontheimer, Erik J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282205/
https://ncbi.nlm.nih.gov/pubmed/30514786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02321-18
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