MMB triazole analogues are potent NF-κB inhibitors and anti-cancer agents against both hematological and solid tumor cells

Triazole derivatives of melampomagnolide B (MMB) have been synthesized via click chemistry methodologies and screened against a panel of 60 human cancer cell lines. Several derivatives showed promising anti-cancer activity, affording growth inhibition (GI(50)) values in the nanomolar range (GI(50) =...

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Publicado no:Eur J Med Chem
Main Authors: Janganati, Venumadhav, Ponder, Jessica, Balasubramaniam, Meenakshisundaram, Bhat-Nakshatri, Poornima, Bar, Eli E., Nakshatri, Harikrishna, Jordan, Craig T., Crooks, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281399/
https://ncbi.nlm.nih.gov/pubmed/30121494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.08.010
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