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MMB triazole analogues are potent NF-κB inhibitors and anti-cancer agents against both hematological and solid tumor cells
Triazole derivatives of melampomagnolide B (MMB) have been synthesized via click chemistry methodologies and screened against a panel of 60 human cancer cell lines. Several derivatives showed promising anti-cancer activity, affording growth inhibition (GI(50)) values in the nanomolar range (GI(50) =...
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| Gepubliceerd in: | Eur J Med Chem |
|---|---|
| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6281399/ https://ncbi.nlm.nih.gov/pubmed/30121494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.08.010 |
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