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Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells

A series of novel, heteroaryl carboxylic acid conjugates of the sesquiterpene melampomagnolide-B (MMB, 3) has been evaluated as antitumor agents against an NCI panel of 64 human hematopoetic and solid tumor cell lines. The indole-3-acrylic acid conjugate 7j and the indole-3-carboxylic acid conjugate...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Bommagani, Shobanbabu, Ponder, Jessica, Penthala, Narsimha R., Janganati, Venumadhav, Jordan, Craig T., Borrelli, Michael J., Crooks, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531865/
https://ncbi.nlm.nih.gov/pubmed/28525840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.05.031
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