Computational affinity maturation of camelid single-domain intrabodies against the nonamyloid component of alpha-synuclein

Improving the affinity of protein-protein interactions is a challenging problem that is particularly important in the development of antibodies for diagnostic and clinical use. Here, we used structure-based computational methods to optimize the binding affinity of V(H)NAC1, a single-domain intracell...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Mahajan, Sai Pooja, Meksiriporn, Bunyarit, Waraho-Zhmayev, Dujduan, Weyant, Kevin B., Kocer, Ilkay, Butler, David C., Messer, Anne, Escobedo, Fernando A., DeLisa, Matthew P.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279780/
https://ncbi.nlm.nih.gov/pubmed/30514850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35464-7
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