PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia

The tendency of mitochondria to undergo or resist BCL2-controlled apoptosis (so-called mitochondrial priming) is a powerful predictor of response to cytotoxic chemotherapy. Fully exploiting this finding will require unraveling the molecular genetics underlying phenotypic variability in mitochondrial...

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Bibliografiska uppgifter
I publikationen:J Exp Med
Huvudupphovsmän: Ariës, Ingrid M., Bodaar, Kimberly, Karim, Salmaan A., Chonghaile, Triona Ni, Hinze, Laura, Burns, Melissa A., Pfirrmann, Maren, Degar, James, Landrigan, Jack T., Balbach, Sebastian, Peirs, Sofie, Menten, Björn, Isenhart, Randi, Stevenson, Kristen E., Neuberg, Donna S., Devidas, Meenakshi, Loh, Mignon L., Hunger, Stephen P., Teachey, David T., Rabin, Karen R., Winter, Stuart S., Dunsmore, Kimberly P., Wood, Brent L., Silverman, Lewis B., Sallan, Stephen E., Van Vlierberghe, Pieter, Orkin, Stuart H., Knoechel, Birgit, Letai, Anthony G., Gutierrez, Alejandro
Materialtyp: Artigo
Språk:Inglês
Publicerad: Rockefeller University Press 2018
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279404/
https://ncbi.nlm.nih.gov/pubmed/30404791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180570
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