PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia

The tendency of mitochondria to undergo or resist BCL2-controlled apoptosis (so-called mitochondrial priming) is a powerful predictor of response to cytotoxic chemotherapy. Fully exploiting this finding will require unraveling the molecular genetics underlying phenotypic variability in mitochondrial...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Ariës, Ingrid M., Bodaar, Kimberly, Karim, Salmaan A., Chonghaile, Triona Ni, Hinze, Laura, Burns, Melissa A., Pfirrmann, Maren, Degar, James, Landrigan, Jack T., Balbach, Sebastian, Peirs, Sofie, Menten, Björn, Isenhart, Randi, Stevenson, Kristen E., Neuberg, Donna S., Devidas, Meenakshi, Loh, Mignon L., Hunger, Stephen P., Teachey, David T., Rabin, Karen R., Winter, Stuart S., Dunsmore, Kimberly P., Wood, Brent L., Silverman, Lewis B., Sallan, Stephen E., Van Vlierberghe, Pieter, Orkin, Stuart H., Knoechel, Birgit, Letai, Anthony G., Gutierrez, Alejandro
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279404/
https://ncbi.nlm.nih.gov/pubmed/30404791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180570
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