PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia

The tendency of mitochondria to undergo or resist BCL2-controlled apoptosis (so-called mitochondrial priming) is a powerful predictor of response to cytotoxic chemotherapy. Fully exploiting this finding will require unraveling the molecular genetics underlying phenotypic variability in mitochondrial...

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Vydáno v:J Exp Med
Hlavní autoři: Ariës, Ingrid M., Bodaar, Kimberly, Karim, Salmaan A., Chonghaile, Triona Ni, Hinze, Laura, Burns, Melissa A., Pfirrmann, Maren, Degar, James, Landrigan, Jack T., Balbach, Sebastian, Peirs, Sofie, Menten, Björn, Isenhart, Randi, Stevenson, Kristen E., Neuberg, Donna S., Devidas, Meenakshi, Loh, Mignon L., Hunger, Stephen P., Teachey, David T., Rabin, Karen R., Winter, Stuart S., Dunsmore, Kimberly P., Wood, Brent L., Silverman, Lewis B., Sallan, Stephen E., Van Vlierberghe, Pieter, Orkin, Stuart H., Knoechel, Birgit, Letai, Anthony G., Gutierrez, Alejandro
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2018
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279404/
https://ncbi.nlm.nih.gov/pubmed/30404791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180570
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