TNFR2/BIRC3-TRAF1 signaling pathway as a novel NK cell immune checkpoint in cancer

Natural Killer (NK) cells control metastatic dissemination of murine tumors and are an important prognostic factor in several human malignancies. However, tumor cells hijack many of the NK cell functional features compromising their tumoricidal activity. Here, we show a deleterious role of the TNFα/...

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Pubblicato in:Oncoimmunology
Autori principali: Ivagnès, Alexandre, Messaoudene, Meriem, Stoll, Gautier, Routy, Bertrand, Fluckiger, Aurélie, Yamazaki, Takahiro, Iribarren, Kristina, Duong, Connie P. M., Fend, Laetitia, Caignard, Anne, Cremer, Isabelle, LeCesne, Axel, Adam, Julien, Honoré, Charles, Mir, Olivier, Chaigneau, Loïc, Berger, Anne, Validire, Pierre, Christidis, Christos, Brun-Ly, Valérie Le, Smyth, Mark J., Mariette, Xavier, Salomon, Benoît L., Kroemer, Guido, Rusakiewicz, Sylvie, Zitvogel, Laurence
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2017
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279330/
https://ncbi.nlm.nih.gov/pubmed/30524877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1386826
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