Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

Visualization of amyloid-β (Aβ) pathology with PET has become an important tool for making a specific clinical diagnosis of Alzheimer disease (AD). However, the available amyloid PET radioligands, such as (11)C-Pittsburgh compound B, reflect levels of insoluble Aβ plaques but do not capture soluble...

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Bibliografiske detaljer
Udgivet i:J Nucl Med
Main Authors: Meier, Silvio R., Syvänen, Stina, Hultqvist, Greta, Fang, Xiaotian T., Roshanbin, Sahar, Lannfelt, Lars, Neumann, Ulf, Sehlin, Dag
Format: Artigo
Sprog:Inglês
Udgivet: Society of Nuclear Medicine 2018
Fag:
Neurology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6278900/
https://ncbi.nlm.nih.gov/pubmed/29853653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.118.213140
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