2-(4-Methylsulfonylphenyl)pyrimidines as Prospective Radioligands for Imaging Cyclooxygenase-2 with PET—Synthesis, Triage, and Radiolabeling

Cyclooxygenase 2 (COX-2) is an inducible enzyme responsible for the conversion of arachidonic acid into the prostaglandins, PGG2 and PGH2. Expression of this enzyme increases in inflammation. Therefore, the development of probes for imaging COX-2 with positron emission tomography (PET) has gained in...

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Publicado en:Molecules
Main Authors: Cortes-Salva, Michelle Y., Shrestha, Stal, Singh, Prachi, Morse, Cheryl L., Jenko, Kimberly J., Montero Santamaria, Jose A., Zoghbi, Sami S., Innis, Robert B., Pike, Victor W.
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6278313/
https://ncbi.nlm.nih.gov/pubmed/30400142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23112850
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