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The oncogene KRAS promotes cancer cell dissemination by stabilizing spheroid formation via the MEK pathway

BACKGROUND: Peritoneal dissemination is a critical prognostic factor in ovarian cancer. Although stabilized spheroid formation promotes cancer cell peritoneal dissemination in ovarian cancer, the associated oncogenes are unknown. In this study, we assessed the role of the KRAS oncogene in ovarian ca...

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Détails bibliographiques
Publié dans:BMC Cancer
Auteurs principaux: Ogishima, Juri, Taguchi, Ayumi, Kawata, Akira, Kawana, Kei, Yoshida, Mitsuyo, Yoshimatsu, Yuki, Sato, Masakazu, Nakamura, Hiroe, Kawata, Yoshiko, Nishijima, Akira, Fujimoto, Asaha, Tomio, Kensuke, Adachi, Katsuyuki, Nagamatsu, Takeshi, Oda, Katsutoshi, Kiyono, Tohru, Osuga, Yutaka, Fujii, Tomoyuki
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6278087/
https://ncbi.nlm.nih.gov/pubmed/30509235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4922-4
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