The oncogene KRAS promotes cancer cell dissemination by stabilizing spheroid formation via the MEK pathway

BACKGROUND: Peritoneal dissemination is a critical prognostic factor in ovarian cancer. Although stabilized spheroid formation promotes cancer cell peritoneal dissemination in ovarian cancer, the associated oncogenes are unknown. In this study, we assessed the role of the KRAS oncogene in ovarian ca...

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Vydáno v:BMC Cancer
Hlavní autoři: Ogishima, Juri, Taguchi, Ayumi, Kawata, Akira, Kawana, Kei, Yoshida, Mitsuyo, Yoshimatsu, Yuki, Sato, Masakazu, Nakamura, Hiroe, Kawata, Yoshiko, Nishijima, Akira, Fujimoto, Asaha, Tomio, Kensuke, Adachi, Katsuyuki, Nagamatsu, Takeshi, Oda, Katsutoshi, Kiyono, Tohru, Osuga, Yutaka, Fujii, Tomoyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6278087/
https://ncbi.nlm.nih.gov/pubmed/30509235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4922-4
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