Intravenous Delivery of Oncolytic Reovirus to Brain Tumor Patients Immunologically Primes for Subsequent Checkpoint Blockade

Immune checkpoint inhibitors, including those targeting programmed cell death protein 1 (PD-1), are reshaping cancer therapeutic strategies. Evidence suggests, however, that tumor response and patient survival are determined by tumor programmed death-ligand 1 (PD-L1) expression. We hypothesized that...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Samson, Adel, Scott, Karen J., Taggart, David, West, Emma J., Wilson, Erica, Nuovo, Gerard J., Thomson, Simon, Corns, Robert, Mathew, Ryan K., Fuller, Martin J., Kottke, Timothy J., Thompson, Jill M., Ilett, Elizabeth J., Cockle, Julia V., van Hille, Philip, Sivakumar, Gnanamurthy, Polson, Euan S., Turnbull, Samantha J., Appleton, Elizabeth S., Migneco, Gemma, Rose, Ailsa S., Coffey, Matthew C., Beirne, Deborah A., Collinson, Fiona J., Ralph, Christy, Anthoney, D. Alan, Twelves, Christopher J., Furness, Andrew J., Quezada, Sergio A., Wurdak, Heiko, Errington-Mais, Fiona, Pandha, Hardev, Harrington, Kevin J., Selby, Peter J., Vile, Richard G., Griffin, Stephen D., Stead, Lucy F., Short, Susan C., Melcher, Alan A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6276984/
https://ncbi.nlm.nih.gov/pubmed/29298869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aam7577
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