Intravenous Delivery of Oncolytic Reovirus to Brain Tumor Patients Immunologically Primes for Subsequent Checkpoint Blockade

Immune checkpoint inhibitors, including those targeting programmed cell death protein 1 (PD-1), are reshaping cancer therapeutic strategies. Evidence suggests, however, that tumor response and patient survival are determined by tumor programmed death-ligand 1 (PD-L1) expression. We hypothesized that...

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Publicado en:Sci Transl Med
Autores principales: Samson, Adel, Scott, Karen J., Taggart, David, West, Emma J., Wilson, Erica, Nuovo, Gerard J., Thomson, Simon, Corns, Robert, Mathew, Ryan K., Fuller, Martin J., Kottke, Timothy J., Thompson, Jill M., Ilett, Elizabeth J., Cockle, Julia V., van Hille, Philip, Sivakumar, Gnanamurthy, Polson, Euan S., Turnbull, Samantha J., Appleton, Elizabeth S., Migneco, Gemma, Rose, Ailsa S., Coffey, Matthew C., Beirne, Deborah A., Collinson, Fiona J., Ralph, Christy, Anthoney, D. Alan, Twelves, Christopher J., Furness, Andrew J., Quezada, Sergio A., Wurdak, Heiko, Errington-Mais, Fiona, Pandha, Hardev, Harrington, Kevin J., Selby, Peter J., Vile, Richard G., Griffin, Stephen D., Stead, Lucy F., Short, Susan C., Melcher, Alan A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6276984/
https://ncbi.nlm.nih.gov/pubmed/29298869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aam7577
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