Intravenous Delivery of Oncolytic Reovirus to Brain Tumor Patients Immunologically Primes for Subsequent Checkpoint Blockade

Immune checkpoint inhibitors, including those targeting programmed cell death protein 1 (PD-1), are reshaping cancer therapeutic strategies. Evidence suggests, however, that tumor response and patient survival are determined by tumor programmed death-ligand 1 (PD-L1) expression. We hypothesized that...

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Publicado no:Sci Transl Med
Main Authors: Samson, Adel, Scott, Karen J., Taggart, David, West, Emma J., Wilson, Erica, Nuovo, Gerard J., Thomson, Simon, Corns, Robert, Mathew, Ryan K., Fuller, Martin J., Kottke, Timothy J., Thompson, Jill M., Ilett, Elizabeth J., Cockle, Julia V., van Hille, Philip, Sivakumar, Gnanamurthy, Polson, Euan S., Turnbull, Samantha J., Appleton, Elizabeth S., Migneco, Gemma, Rose, Ailsa S., Coffey, Matthew C., Beirne, Deborah A., Collinson, Fiona J., Ralph, Christy, Anthoney, D. Alan, Twelves, Christopher J., Furness, Andrew J., Quezada, Sergio A., Wurdak, Heiko, Errington-Mais, Fiona, Pandha, Hardev, Harrington, Kevin J., Selby, Peter J., Vile, Richard G., Griffin, Stephen D., Stead, Lucy F., Short, Susan C., Melcher, Alan A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6276984/
https://ncbi.nlm.nih.gov/pubmed/29298869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aam7577
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