Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle

BACKGROUND: Plasma-derived cell-free tumor DNA (ctDNA) constitutes a potential surrogate for tumor DNA obtained from tissue biopsies. We posit that massively parallel sequencing (MPS) analysis of ctDNA may help define the repertoire of mutations in breast cancer and monitor tumor somatic alterations...

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Detalhes bibliográficos
Publicado no:Ann Oncol
Main Authors: De Mattos-Arruda, L, Weigelt, B, Cortes, J, Won, H H, Ng, C K Y, Nuciforo, P, Bidard, F C, Aura, C, Saura, C, Peg, V, Piscuoglio, S, Oliveira, M, Smolders, Y, Patel, P, Norton, L, Tabernero, J, Berger, M F, Seoane, J, Reis-Filho, J S
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6276937/
https://ncbi.nlm.nih.gov/pubmed/25009010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdu239
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