Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle

BACKGROUND: Plasma-derived cell-free tumor DNA (ctDNA) constitutes a potential surrogate for tumor DNA obtained from tissue biopsies. We posit that massively parallel sequencing (MPS) analysis of ctDNA may help define the repertoire of mutations in breast cancer and monitor tumor somatic alterations...

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Detaylı Bibliyografya
Yayımlandı:Ann Oncol
Asıl Yazarlar: De Mattos-Arruda, L, Weigelt, B, Cortes, J, Won, H H, Ng, C K Y, Nuciforo, P, Bidard, F C, Aura, C, Saura, C, Peg, V, Piscuoglio, S, Oliveira, M, Smolders, Y, Patel, P, Norton, L, Tabernero, J, Berger, M F, Seoane, J, Reis-Filho, J S
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2014
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6276937/
https://ncbi.nlm.nih.gov/pubmed/25009010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdu239
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