Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle

BACKGROUND: Plasma-derived cell-free tumor DNA (ctDNA) constitutes a potential surrogate for tumor DNA obtained from tissue biopsies. We posit that massively parallel sequencing (MPS) analysis of ctDNA may help define the repertoire of mutations in breast cancer and monitor tumor somatic alterations...

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Publicat a:Ann Oncol
Autors principals: De Mattos-Arruda, L, Weigelt, B, Cortes, J, Won, H H, Ng, C K Y, Nuciforo, P, Bidard, F C, Aura, C, Saura, C, Peg, V, Piscuoglio, S, Oliveira, M, Smolders, Y, Patel, P, Norton, L, Tabernero, J, Berger, M F, Seoane, J, Reis-Filho, J S
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6276937/
https://ncbi.nlm.nih.gov/pubmed/25009010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdu239
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