The long non-coding RNA NEAT1 is elevated in polyglutamine repeat expansion diseases and protects from disease gene-dependent toxicities

Polyglutamine (polyQ) repeat diseases are a class of neurodegenerative disorders caused by CAG-repeat expansion. There are diverse cellular mechanisms behind the pathogenesis of polyQ disorders, including transcriptional dysregulation. Interestingly, we find that levels of the long isoform of nuclea...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Cheng, Congsheng, Spengler, Ryan M, Keiser, Megan S, Monteys, Alejandro Mas, Rieders, Julianne M, Ramachandran, Shyam, Davidson, Beverly L
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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General Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6276831/
https://ncbi.nlm.nih.gov/pubmed/30239724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy331
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